A new reagent and its polymer-supported variant for the amidination of amines

verfasst von

Gerald Dräger, Wladimir Solodenko, Josef Messinger, Uwe Schön, Andreas Kirschning

Abstract

New reagents for the high yielding amidination of primary and secondary amines are described. By attaching a benzyl substituent to the 3,5-dimethyl-1H-pyrazole-1-carboxamidine ring, a reagent 1 is obtained which allows easy work-up after amidination because of solubility of byproducts in organic solvents. In addition, the polystyrene-bound analogue 2 was prepared which allows amidination of various amines with high purity.

Organisationseinheit(en)

Institut für Organische Chemie

Externe Organisation(en)

SOLVAY GmbH

Typ

Artikel

Journal

Tetrahedron Letters

Band

43

Seiten

1401-1403

Anzahl der Seiten

3

ISSN

0040-4039

Publikationsdatum

03.02.2002

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Biochemie, Wirkstoffforschung, Organische Chemie

Elektronische Version(en)

https://doi.org/10.1016/S0040-4039(01)02403-0 (Zugang: Unbekannt)