Pulsed photothermal radiometry as a method for investigating blood vessel-like structures

authored by: C. H. Schmitz, U. Oberheide, S. Lohmann, H. Lubatschowski, W. Ertmer
Abstract: Pulsed photothermal radiometry (PPTR) is known to be suitable for in vivo investigations of tissue optical properties. As a noncontact, nondestructive method it is a very attractive candidate for on-line dosimetry of laser treatments that rely on thermal laser-tissue interaction. In this article, we extend the one-dimensional (1D) analytical formalism that has widely been used to describe PPTR signals to a two-dimensional treatment of a simplified model of a blood vessel. This approach leads to quantitative description of a PPTR signal that, unlike in an 1D treatment, not only shows changes in time, but also varies in space. Using this approach, we are able to gain instructive understanding on how target characteristics of a blood vessel-like structure influence such a spatiotemporal PPTR signal. Likewise, the ability of extracting target features from those measurements is evaluated. Subsequently, we present experimental realization of the idealized model of a blood vessel as used in our theory. Comparison of actual PPTR measurements with theoretical predictions allow vessel localization laterally and in depth. Using our setup, we furthermore demonstrate the influence of flow inside the vessel on the measured signal.
Organisation(s): Institute of Quantum Optics
External Organisation(s): Laser Zentrum Hannover e.V. (LZH)
Type: Article
Journal: Journal of biomedical optics
Volume: 6
Pages: 214-223
No. of pages: 10
ISSN: 1083-3668
Publication date: 01.04.2001
Publication status: Published
Peer reviewed: Yes
ASJC Scopus subject areas: Electronic, Optical and Magnetic Materials, Biomaterials, Atomic and Molecular Physics, and Optics, Biomedical Engineering
Electronic version(s): https://doi.org/10.1117/1.1344193 (Access: Closed)
https://pdfs.semanticscholar.org/0f9a/dbdf8b0badb7a29745a798147c5c238dd6ec.pdf?_ga=2.147258039.1856112375.1588235090-944926180.1585823162 (Access: Open)

BibTeX

@article{96a9e77f3d6146c0afaebba3b7b1ab6c,
title = "Pulsed photothermal radiometry as a method for investigating blood vessel-like structures",
abstract = "Pulsed photothermal radiometry (PPTR) is known to be suitable for in vivo investigations of tissue optical properties. As a noncontact, nondestructive method it is a very attractive candidate for on-line dosimetry of laser treatments that rely on thermal laser-tissue interaction. In this article, we extend the one-dimensional (1D) analytical formalism that has widely been used to describe PPTR signals to a two-dimensional treatment of a simplified model of a blood vessel. This approach leads to quantitative description of a PPTR signal that, unlike in an 1D treatment, not only shows changes in time, but also varies in space. Using this approach, we are able to gain instructive understanding on how target characteristics of a blood vessel-like structure influence such a spatiotemporal PPTR signal. Likewise, the ability of extracting target features from those measurements is evaluated. Subsequently, we present experimental realization of the idealized model of a blood vessel as used in our theory. Comparison of actual PPTR measurements with theoretical predictions allow vessel localization laterally and in depth. Using our setup, we furthermore demonstrate the influence of flow inside the vessel on the measured signal.",
keywords = "Blood flow, Blood vessels, On-line-dosimetry, Pulsed photothermal radiometry, Thermal imaging, Tissue optics",
author = "Schmitz, {C. H.} and U. Oberheide and S. Lohmann and H. Lubatschowski and W. Ertmer",
year = "2001",
month = apr,
day = "1",
doi = "10.1117/1.1344193",
language = "English",
volume = "6",
pages = "214--223",
journal = "Journal of biomedical optics",
issn = "1083-3668",
publisher = "SPIE",
number = "2",
}